Anti-Human IgM Monoclonal Antibody
产品名称: Anti-Human IgM Monoclonal Antibody
英文名称: Anti-Human IgM Monoclonal Antibody
产品编号: K001450M
产品价格: null
产品产地: 北京
品牌商标: solarbio
更新时间: 2025-02-07T13:54:15
使用范围: ELISA
北京索莱宝科技有限公司
- 联系人 : 索莱宝-龚思雨
- 地址 : 北京市通州区中关村科技园区通州园金桥科技产业基地景盛南四街15号85A三层
- 邮编 : 101102
- 所在区域 : 北京
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Anti-Human IgM Monoclonal Antibody
品牌:solarbio | 货号:K001450M
英文名称 | Anti-Human IgM Monoclonal Antibody |
---|---|
别名 | Human IgM |
应用 | ELISA |
稀释比例 | WB 1:1000. |
交叉反应 | Human |
蛋白分子量 | 75kDa |
Gene ID | 3507 |
保存 | Store at -20°C. Avoid freeze / thaw cycles. |
储存液 | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
纯化方法 | Affinity purification |
亚型 | IgG2a |
免疫原 | Purified recombinant full length of human IgM heavy chain protein expressed in E.coli. |
性状 | 液体 |
Public Immunogen Range | Purified recombinant full length of human IgM heavy chain protein expressed in E.coli. |
Subcellular Locations | Cell membrane Secreted |
Swiss Prot | P01871 |
克隆号 | 3E12-H4-G4 |
克隆类型 | Monoclonal Antibody |
背景资料 | Immunoglobulins (Ig) are the antigen recognition molecules of B cells. An Ig molecule is made up of 2 identical heavy chains and 2 identical light chains (see MIM 147200) joined by disulfide bonds so that each heavy chain is linked to a light chain and the 2 heavy chains are linked together. Each Ig heavy chain has an N-terminal variable (V) region containing the antigen-binding site and a C-terminal constant (C) region, encoded by an individual C region gene, that determines the isotype of the antibody and provides effector or signaling functions. The heavy chain V region is encoded by 1 each of 3 types of genes: V genes (see MIM 147070), joining (J) genes (see MIM 147010), and diversity (D) genes (see MIM 146910). The C region genes are clustered downstream of the V region genes within the heavy chain locus on chromosome 14. The IGHM gene encodes the C region of the mu heavy chain, which defines the IgM isotype. Naive B cells express the transmembrane forms of IgM and IgD (see IGHD; MIM 1471770) on their surface. During an antibody response, activated B cells can switch to the expression of individual downstream heavy chain C region genes by a process of somatic recombination known as isotype switching. In addition, secreted Ig forms that act as antibodies can be produced by alternative RNA processing of the heavy chain C region sequences. Although the membrane forms of all Ig isotypes are monomeric, secreted IgM forms pentamers, and occasionally hexamers, in plasma |