Anti-Human IgM Monoclonal Antibody-抗体-抗体-生物在线
北京索莱宝科技有限公司
Anti-Human IgM Monoclonal Antibody

Anti-Human IgM Monoclonal Antibody

商家询价

产品名称: Anti-Human IgM Monoclonal Antibody

英文名称: Anti-Human IgM Monoclonal Antibody

产品编号: K001450M

产品价格: null

产品产地: 北京

品牌商标: solarbio

更新时间: 2025-02-07T13:54:15

使用范围: ELISA

北京索莱宝科技有限公司
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Anti-Human IgM Monoclonal Antibody

品牌:solarbio | 货号:K001450M
商品货号:商品品牌:规格基本售价:选择规格
K001450M-50ulsolarbio50ul960.00元
K001450M-100ulsolarbio100ul1600.00元
英文名称Anti-Human IgM Monoclonal Antibody
别名Human IgM
应用ELISA
稀释比例WB 1:1000.
交叉反应Human
蛋白分子量75kDa
Gene ID3507
保存Store at -20°C. Avoid freeze / thaw cycles.
储存液Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
纯化方法Affinity purification
亚型IgG2a
免疫原Purified recombinant full length of human IgM heavy chain protein expressed in E.coli.
性状液体
Public Immunogen RangePurified recombinant full length of human IgM heavy chain protein expressed in E.coli.
Subcellular LocationsCell membrane Secreted
Swiss ProtP01871
克隆号3E12-H4-G4
克隆类型Monoclonal Antibody
背景资料Immunoglobulins (Ig) are the antigen recognition molecules of B cells. An Ig molecule is made up of 2 identical heavy chains and 2 identical light chains (see MIM 147200) joined by disulfide bonds so that each heavy chain is linked to a light chain and the 2 heavy chains are linked together. Each Ig heavy chain has an N-terminal variable (V) region containing the antigen-binding site and a C-terminal constant (C) region, encoded by an individual C region gene, that determines the isotype of the antibody and provides effector or signaling functions. The heavy chain V region is encoded by 1 each of 3 types of genes: V genes (see MIM 147070), joining (J) genes (see MIM 147010), and diversity (D) genes (see MIM 146910). The C region genes are clustered downstream of the V region genes within the heavy chain locus on chromosome 14. The IGHM gene encodes the C region of the mu heavy chain, which defines the IgM isotype. Naive B cells express the transmembrane forms of IgM and IgD (see IGHD; MIM 1471770) on their surface. During an antibody response, activated B cells can switch to the expression of individual downstream heavy chain C region genes by a process of somatic recombination known as isotype switching. In addition, secreted Ig forms that act as antibodies can be produced by alternative RNA processing of the heavy chain C region sequences. Although the membrane forms of all Ig isotypes are monomeric, secreted IgM forms pentamers, and occasionally hexamers, in plasma