TNFRSF1B polyclonal antibody
产品名称： TNFRSF1B polyclonal antibody
英文名称： TNFRSF1B polyclonal antibody
产品编号： PAB12329
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of TNFRSF1B.
- Immunogen:
- A synthetic peptide corresponding to amino acids 103-121 at N-terminus of human TNFRSF1B.
- Sequence:
- DQVETQACTREQNRICTCR
- Host:
- Rabbit
- Reactivity:
- Human
- Form:
- Lyophilized
- Purification:
- Immunoaffinity purification
- Storage Buffer:
- Lyophilized from 0.9 mg NaCl, 0.2 mg Na2HPO4 (5 mg BSA, 0.05 mg sodium azide, 0.05 mg Thimerosal)
- Storage Instruction:
- Store at -20°C on dry atmosphere.
After reconstitution with 200 uL of deionized water and concentration will be 500 ug/mL, store at -20°C or lower.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- Western Blot (1 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1 ug/mL)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide and thimerosal: POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Renal cell-expressed TNF receptor 2, not receptor 1, is essential for the development of glomerulonephritis.
Vielhauer V, Stavrakis G, Mayadas TN.J Clin Invest. 2005 May;115(5):1199-209. Epub 2005 Apr 1.
- 2.
- Tumor necrosis factor receptor genes, TNFR1 and TNFR2, on human chromosomes 12 and 1.
Milatovich A, Song K, Heller RA, Francke U.Somat Cell Mol Genet. 1991 Sep;17(5):519-23.
- Entrez GeneID:
- 7133
- Gene Name:
- TNFRSF1B
- Gene Alias:
- CD120b,TBPII,TNF-R-II,TNF-R75,TNFBR,TNFR1B,TNFR2,TNFR80,p75,p75TNFR
- Gene Description:
- tumor necrosis factor receptor superfamily, member 1B
- Omim ID:
- 191191
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways. [provided by RefSeq
- Other Designations:
- OTTHUMP00000001784,p75 TNF receptor,soluble TNFR1B variant 1,tumor necrosis factor beta receptor,tumor necrosis factor binding protein 2,tumor necrosis factor receptor 2
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